Malarone Tablets
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Description
Malarone has two uses:
▪ to prevent malaria
▪ to treat malaria
Malaria is spread by the bite of an infected mosquito, which passes the malaria parasite (Plasmodium
falciparum) into the bloodstream. Malarone prevents malaria by killing this parasite. For people who
are already infected with malaria, Malarone also kills these parasites.
Protect yourself from catching malaria
People of any age can get malaria. It is a serious disease, but is preventable.
As well as taking Malarone, it is very important that you also take steps to avoid being bitten by
mosquitoes.
▪ Use insect repellent on exposed areas of the skin
▪ Wear light coloured clothing that covers most of the body, especially after sunset as this is the time when mosquitoes are most active
▪ Sleep in a screened room or under a mosquito net impregnated with insecticide
▪ Close windows and doors at sunset, if they are not screened
▪ Consider using an insecticide (mats, spray, plug-ins) to clear a room of insects or to deter mosquitoes from entering the room.
If you need further advice, talk to your doctor or pharmacist.
It is still possible to get malaria after taking the necessary precautions. Some types of malaria
infection take a long time to cause symptoms, so the illness may not start until several days, weeks or
even months after returning from abroad.
Warnings
Do not take Malarone:
▪ if you are allergic to atovaquone, proguanil hydrochloride or any of the ingredients of this
medicine listed.
▪ for preventing malaria, if you have severe kidney disease.
Tell your doctor if either of these apply to you.
Take special care with Malarone
Talk to your doctor or pharmacist before taking Malarone if:
▪ you have severe kidney disease
▪ your child is being treated for Malaria and weighs less than 11 kg. There is another tablet strength to treat children who weigh less than 11 kg.
Tell your doctor or pharmacist if any of these applies to you.
Do not breast-feed while taking Malarone, as the ingredients of Malarone may pass into breast milk
and may harm your baby.
Directions
Always take this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
Take Malarone with food or a milky drink, where possible.
It is best to take Malarone at the same time each day.
Ingredients
The active ingredients are: 250 mg of atovaquone and 100 mg of proguanil hydrochloride in each
tablet.
The other ingredients are:
tablet core: poloxamer 188, microcrystalline cellulose, hydroxypropyl cellulose, povidone K30,
sodium starch glycollate (Type A), magnesium stearate
tablet coating: hypromellose, titanium dioxide (E171), iron oxide red (E172), macrogol 400 and
polyethylene glycol 8000 (see section 2).
Side Effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Look out for the following severe reactions. They have occurred in a small number of people, but their
exact frequency is unknown.
Severe allergic reactions - signs include:
▪ rash and itching
▪ sudden wheezing, tightness of the chest or throat, or difficulty breathing
▪ swollen eyelids, face, lips, tongue or other part of the body.
Contact a doctor immediately if you get any of these symptoms. Stop taking Malarone.
Very common side effects
These may affect more than 1 in 10 people:
▪ headache
▪ feeling sick and being sick (nausea and vomiting)
▪ stomach pain
▪ diarrhoea.
Common side effects
These may affect up to 1 in 10 people:
▪ dizziness
▪ sleeping problems (insomnia)
▪ strange dreams
▪ depression
▪ loss of appetite
▪ fever
▪ rash which may be itchy
▪ cough
