If you are looking for a clinically supported way to lose weight, Orlistat can be a helpful option for many people in the UK. It is one of the most established prescription weight loss treatments and works differently to newer appetite-suppressing injections. Instead of changing hunger hormones, Orlistat helps reduce the amount of fat your body absorbs from food.
This step-by-step Orlistat UK guide from The Care Pharmacy explains how to use Orlistat safely, what results you can expect, and how to improve your chances of success with realistic changes you can maintain long term. If you would like personalised advice, contact us or start an online consultation, and we will guide you through the best next step.
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Step 1: Understand What Orlistat Does
Orlistat, also known as Xenical, works by blocking enzymes in your gut that break down fat. This means some of the fat you eat is not absorbed and passes through your digestive system instead.
What this means in practice:
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- Orlistat supports weight loss when you reduce your calorie intake
- The medication is most effective when paired with a lower-fat diet
- Eating too much fat can increase side effects
Step 2: Check If Orlistat Is Right For You
Orlistat is not suitable for everyone. In the UK, it is typically considered for people with a higher BMI, particularly if weight is affecting health or daily life.
Orlistat may be an option if:
- You have tried diet and exercise changes without enough progress
- You want a non-injection treatment
- You prefer a medication that supports weight loss through fat absorption reduction
It may not be suitable if you have certain digestive conditions or are pregnant or breastfeeding. A proper clinical assessment is essential. Start an online consultation with The Care Pharmacy to check eligibility safely.

Step 3: Set A Realistic Weight Loss Target
A helpful goal is steady weight loss rather than rapid changes. Even a modest reduction in weight can support improvements in health markers like blood pressure and cholesterol.
A realistic approach could include:
- Aiming for gradual weekly progress
- Tracking weight alongside waist measurement
- Focusing on habits rather than perfection
If you want support building a plan that fits your lifestyle, contact us today.
Step 4: Plan Your Meals Around Lower-Fat Choices
Orlistat works best when you keep meals balanced and avoid high-fat foods. This does not mean removing fat completely, but it does mean being mindful of portions and food choices.
Lower-fat meal ideas include:
- Grilled chicken, turkey, or fish
- Beans, lentils, and chickpeas
- Vegetables, salads, and soups
- Potatoes, rice, and wholegrain pasta
- Low-fat yoghurt and cottage cheese
If you are unsure what to eat while taking Orlistat, start an online consultation, and we can provide guidance.
Step 5: Take Orlistat Correctly
Orlistat is usually taken with meals that contain fat. If you skip a meal or eat a meal with no fat, you may not need a dose.
A simple routine is:
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- Take Orlistat with each main meal
- Take it during the meal or up to one hour after
- Do not double up doses if you miss one
Step 6: Know The Side Effects And How To Reduce Them
Side effects are often linked to how much fat you eat. This is why diet changes are such an important part of Orlistat success.
Common side effects can include:
- Oily stools
- Increased urgency to use the toilet
- More frequent bowel movements
- Stomach discomfort
To reduce side effects:
- Keep meals lower in fat
- Avoid fried foods and creamy sauces
- Spread fat intake evenly across the day
- Choose lean proteins and high-fibre foods
If side effects are difficult to manage, contact us, and we can advise you on adjustments.

Step 7: Support Your Results With A Simple Activity Plan
You do not need to start intense workouts to see progress. Small, consistent changes are often easier to maintain.
A simple weekly plan could include:
- A daily walk after meals
- Two to three short strength sessions per week
- More movement throughout the day, such as stairs or active breaks
If you would like a structured plan alongside treatment, start an online consultation form with The Care Pharmacy.
Step 8: Track Progress Beyond The Scales
Weight can fluctuate due to water retention, hormones, and digestion. Tracking more than just weight can keep you motivated.
Helpful measures include:
- Waist measurement
- How your clothes fit
- Energy levels and sleep quality
- Appetite and snacking habits
- Fitness improvements, such as walking distance
If you want help understanding your progress, reach out to us, and we will support you.
Step 9: Take The Right Supplements
Because Orlistat reduces fat absorption, it can also reduce absorption of fat-soluble vitamins such as A, D, E, and K.
Many people are advised to take a multivitamin while using Orlistat. It is often recommended to take this at a different time of day, such as before bed, rather than alongside Orlistat. We can advise on the best supplements for you.
Step 10: Review Your Results And Consider Next Steps
Orlistat can be a great option for UK patients who want a non-injection route to weight loss, but it is not the only choice. If you are not seeing progress or if your appetite is still difficult to manage, it may be time to review your treatment plan.
At The Care Pharmacy, we also offer injectable weight loss treatments such as Wegovy and Mounjaro. These options work differently from Orlistat and may suit people who need stronger appetite support or prefer a weekly routine.
If you would like to explore Orlistat, Wegovy, or Mounjaro, contact us or start an online consultation, and we will help you choose the most suitable option.
Orlistat UK Support That Fits Your Lifestyle
Orlistat can support steady weight loss when paired with a balanced, lower-fat diet and realistic lifestyle changes. The key is following a structured approach, understanding how the medication works, and staying consistent week by week.
If you are ready to begin your Orlistat UK weight loss journey, contact us today or start an online consultation with The Care Pharmacy for personalised support. Book now.
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This blog was written in collaboration with Pharmacy Mentor.
Medically reviewed by
Mohammed Lakhi
Superintendent Pharmacist