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Quviviq (Daridorexant)

(3 customer reviews)

Price range: £62.99 through £64.99

Buy Quviviq Tablets Online. Quviviq (daridorexant) is a prescription-only tablet licensed in the UK for adults with long-term insomnia. It works differently to traditional sleeping tablets by quietening the brain’s wake signal, helping you fall asleep faster, stay asleep longer and function better the next day.

  • Supplied as one box of 30 tablets (25mg or 50mg)
  • Not a benzodiazepine or Z-drug
  • Recommended by NICE for long-term insomnia where CBT-I has not worked or is unavailable
  • Reviewed by our GPhC-registered UK pharmacy team before every supply
  • Discreet, tracked UK delivery in plain packaging

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Prescription-only medicine. Subject to a short online consultation and clinical approval by our prescriber. Treatment is not guaranteed.

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Type of medicine

Prescription tablet for insomnia in adults who struggle to fall or stay asleep

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Active Ingredient

Daridorexant, a dual orexin receptor antagonist (DORA)

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Effective within

Typically starts working within around 30 minutes of taking

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Works by

Blocking orexin, the brain chemical that keeps you awake, so the brain can settle into sleep

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Side effects

May cause headache or next-day sleepiness

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Not Suitable For

People with narcolepsy; do not use with alcohol

Buy Quviviq Tablets for Long-Term Insomnia

Quviviq is a prescription sleep treatment containing daridorexant, licensed for adults whose insomnia has lasted at least three months and is noticeably affecting how they function during the day. Unlike older sleeping tablets that sedate the brain, Quviviq blocks orexin, the chemical that keeps you alert, allowing your body’s natural sleep drive to take over. The result is falling asleep sooner, waking less often through the night, and feeling more like yourself the following morning.

If you have been cycling through poor nights for months, relying on over-the-counter remedies, or worrying about becoming dependent on traditional sleeping tablets, Quviviq offers a different route. Our UK-based clinical team will review your consultation and confirm whether it is a safe and suitable option for you.

Why patients choose Quviviq

  • Targets the night and the day. Clinical trials measured both sleep improvement and next-day functioning.
  • Designed for morning clarity. Daridorexant has a shorter half-life of around eight hours, so it is less likely to linger than longer-acting sedatives.
  • Not a benzodiazepine or Z-drug. Studies did not show rebound insomnia or withdrawal symptoms on stopping, and no tapering is normally required.
  • Suitable for longer-term use. Evidence supports benefit maintained over 12 months, with regular clinical review.
  • One box of 30 tablets. A full month of treatment, delivered discreetly.

How Quviviq works

Your brain produces orexin to keep you awake and alert. In many people with chronic insomnia, that wake signal stays switched on when it should be winding down. Quviviq is a dual orexin receptor antagonist, meaning it blocks both orexin receptors and turns down the overactive wake signal rather than forcing sedation. Because it works with your sleep-wake system instead of overriding it, sleep tends to feel more natural.

Most people notice an improvement within the first few nights, although the full picture is usually clearer after two to four weeks of consistent use alongside good sleep habits.

Who Quviviq is suitable for

Quviviq is licensed for adults with insomnia symptoms present for at least three months that considerably affect daytime functioning. NICE guidance on Quviviq (daridorexant) recommends it where cognitive behavioural therapy for insomnia (CBT-I) has been tried without success, or where CBT-I is not available or not suitable.

It is not suitable if you have narcolepsy, severe liver problems, or a known allergy to daridorexant. Our prescriber will also review any medicines you take that could interact, along with any history of depression, breathing conditions or previous falls.

How to take Quviviq

The usual adult dose is one 50mg tablet each night. A 25mg dose may be prescribed if you have moderate liver impairment or take certain interacting medicines.

  • Take one tablet in the evening, within 30 minutes of going to bed
  • Allow at least seven hours before you need to be awake
  • Taking it with a large meal may delay how quickly it works
  • Do not drink alcohol while taking Quviviq
  • Do not drive or use machinery unless you feel fully alert, particularly in the first few days

Getting Quviviq UK patients can rely on

Buying Quviviq UK-wide should be straightforward, but it should never be automatic. Every request placed with The Care Pharmacy is reviewed by our clinical team before any medicine is dispensed. We are registered with the General Pharmaceutical Council and every order is checked by a UK pharmacist.

  1. Complete a short consultation. Tell us about your sleep, your health and any medicines you take.
  2. Clinical review. Our prescriber confirms whether Quviviq is safe and appropriate, and which strength suits you.
  3. Dispensed and dispatched. Your box of 30 tablets is dispensed by our UK pharmacy and sent in discreet, tracked packaging.
  4. Ongoing support. Treatment is reviewed within three months so we can check it is still the right fit for you.

Ready to sleep properly again?

Start your online consultation and our clinicians will let you know whether Quviviq is right for you.

Request Treatment

Got a question first? Chat with us using the icon in the corner of your screen and one of our team will help.

Important safety information

Who should not take Quviviq

Do not take Quviviq if you are allergic to daridorexant or any other ingredient, or if you have narcolepsy. It is not recommended if you have severe liver problems, or if you take strong CYP3A4 inhibitors such as ketoconazole, itraconazole, clarithromycin or ritonavir. Quviviq is not licensed for anyone under 18.

Tell your prescriber before starting

Let us know if you have any liver problems, a history of depression or thoughts of self-harm, a history of drug or alcohol misuse, breathing difficulties such as severe COPD or sleep apnoea, or if you are over 65 with a history of falls. Also tell us if you are pregnant, planning a pregnancy or breastfeeding, as Quviviq is not recommended during pregnancy.

Driving, alcohol and other medicines

Do not drive or operate machinery until you know how Quviviq affects you, and avoid these activities if you have slept for fewer than seven hours. Alcohol should be avoided completely. Quviviq should not be combined with other sleeping tablets. Always tell us about every medicine you take, including anything bought without a prescription.

Storage and disposal

Store below 30°C in the original blister pack, out of the sight and reach of children. Do not use after the expiry date printed on the pack. Return any unused tablets to a pharmacy for safe disposal rather than putting them in household waste.

The Care Pharmacy is registered with the General Pharmaceutical Council (registration number 9010308). Superintendent Pharmacist: Mohammed Ismail Lakhi (MPharm MRPharmS, GPhC 2072815). This page is for information only and does not replace advice from a qualified healthcare professional.

3 reviews for Quviviq (Daridorexant)

  1. Stella

    Excellent service from start to finish. I received updates on my order and it arrived promptly.

  2. George

    Really straightforward ordering process and my parcel arrived the next day. Everything was well packaged and discreet.

  3. Mohammad

    Good place to buy Quviviq online. Good consultation service. Probably the cheapest on the market.

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How to take Quviviq

Always take Quviviq exactly as your prescriber has told you. The instructions below reflect the licensed directions, but your prescriber’s advice takes priority if it differs.

Your dose at a glance

Standard adult dose: one 50mg tablet once per night

Reduced dose: one 25mg tablet once per night, where prescribed for moderate liver impairment or alongside certain interacting medicines

When to take it: in the evening, within 30 minutes of going to bed

Maximum: one tablet in any 24 hour period

Step by step

  1. Plan your night. Only take your tablet when you can stay in bed for at least seven hours before you need to be awake and alert.
  2. Leave a gap after a large meal. Quviviq can be taken with or without food, but a heavy meal shortly beforehand can delay how quickly it works.
  3. Swallow the tablet whole with water. Do not crush, split or chew it.
  4. Go straight to bed. Take your tablet within 30 minutes of settling down for the night.
  5. Keep the routine consistent. Taking Quviviq at a similar time each night, alongside a regular wake time, gives you the best chance of a lasting improvement.

If you forget a dose

Skip the missed dose and take your next tablet the following evening as normal. Never take two tablets to make up for a missed one, and do not take a tablet during the night if you have fewer than seven hours before you need to get up.

If you take too much

Taking more than one tablet increases drowsiness and the risk of side effects. Contact 111 for advice, or attend your nearest A&E if you feel unwell, taking the pack with you.

Stopping Quviviq

Quviviq can normally be stopped without gradually reducing the dose, and studies did not show rebound insomnia or withdrawal effects. Even so, speak to us or your prescriber before stopping so we can review your sleep and agree the right next step. Your treatment should be assessed within three months of starting, and at regular intervals after that.

Getting the most from your treatment

Medication works best alongside consistent sleep habits. Keep the same wake time every day including weekends, use your bed only for sleep, limit caffeine after early afternoon, avoid alcohol, and get up and do something quiet if you are still awake after around 20 minutes rather than lying there frustrated.

Quviviq ingredients

Quviviq is manufactured by Idorsia Pharmaceuticals and supplied as film-coated tablets in blister packs of 30. The active and inactive ingredients are listed below so you can check them against any known allergies before starting treatment.

Active ingredient

Quviviq 25mg: daridorexant hydrochloride, equivalent to 25mg of daridorexant per tablet

Quviviq 50mg: daridorexant hydrochloride, equivalent to 50mg of daridorexant per tablet

Tablet core

  • Mannitol (E421)
  • Microcrystalline cellulose (E460)
  • Povidone
  • Croscarmellose sodium
  • Silicon dioxide
  • Magnesium stearate

Film coating

  • Hypromellose (E464)
  • Microcrystalline cellulose (E460)
  • Glycerol
  • Talc (E553)
  • Titanium dioxide (E171)
  • Iron oxide red (E172)
  • Iron oxide black (E172)
  • Iron oxide yellow (E172), in the 50mg tablets only

Sodium content

Each Quviviq tablet contains less than 1mmol of sodium (23mg), which means it is essentially sodium-free.

What Quviviq tablets look like

  • 25mg: light purple, arc-triangle shaped tablet marked with 25 on one side and the Idorsia logo on the other
  • 50mg: light orange, arc-triangle shaped tablet marked with 50 on one side and the Idorsia logo on the other

Pack size and storage

Supplied as one box of 30 film-coated tablets in blister strips. Store below 30°C in the original packaging and do not use after the expiry date printed on the carton. Return any unused tablets to a pharmacy for safe disposal.

Marketing authorisation holder: Idorsia Pharmaceuticals UK Ltd.

If you have an allergy or intolerance you are unsure about, chat with us before ordering, or Request Treatment and flag it in your consultation.

Quviviq side effects

Like all medicines, Quviviq can cause side effects, although not everybody gets them. In clinical studies most reactions were mild to moderate, and the frequency did not increase at the higher 50mg dose. The list below is a summary rather than a complete record.

Common (may affect up to 1 in 10 people)

  • Headache
  • Drowsiness or sleepiness during the day
  • Tiredness or fatigue
  • Dizziness
  • Nausea
  • Vivid or abnormal dreams

Uncommon (may affect up to 1 in 100 people)

  • Sleep paralysis, a temporary inability to move or speak as you fall asleep or wake up
  • Hallucinations as you fall asleep or wake up
  • Brief muscle weakness resembling mild cataplexy

These effects usually occur in the first few weeks of treatment. They can be unsettling but are not dangerous. Contact us or your GP if they happen so we can review your treatment.

Seek medical advice straight away if you experience

  • Swelling of the face, lips, tongue or throat, or difficulty breathing or swallowing, which may indicate a serious allergic reaction
  • Low mood becoming worse, or any thoughts of harming yourself
  • Carrying out activities while not fully awake with no memory of them afterwards

Stop taking Quviviq and contact a healthcare professional or call 111. In an emergency, call 999.

Reporting side effects

You can report any suspected side effect from Quviviq directly through the MHRA Yellow Card Scheme. Reporting helps provide more information on the safety of this medicine. If something does not feel right on treatment, chat with us and our pharmacy team will talk it through with you.

Quviviq warnings and precautions

Quviviq is a prescription-only medicine and must only be taken by the person it was prescribed for. Read the information below and the leaflet inside your pack before taking your first tablet. If anything is unclear, speak to our pharmacy team before you start.

Do not take Quviviq if you

  • Are allergic to daridorexant or any of the other ingredients listed in this pack
  • Have narcolepsy, a condition causing you to fall asleep suddenly and unexpectedly
  • Take a strong CYP3A4 inhibitor, including oral antifungals such as ketoconazole, itraconazole, posaconazole or voriconazole, or antibiotics such as clarithromycin, josamycin, telithromycin or troleandomycin
  • Have severe liver impairment
  • Are under 18 years of age

Speak to us before taking Quviviq if you

  • Have any liver problems, as a lower 25mg dose may be needed or treatment may not be suitable
  • Have depression or a history of low mood, or have ever had thoughts of harming yourself
  • Have a history of drug or alcohol misuse
  • Have breathing difficulties, including severe chronic obstructive pulmonary disease or obstructive sleep apnoea
  • Are over 65 and have a history of falls, as your response may need closer monitoring
  • Are over 75, as there is limited data in this age group
  • Are pregnant, planning a pregnancy or breastfeeding, as Quviviq is not recommended during pregnancy and it is not known whether it passes into breast milk in significant amounts

Alcohol, driving and machinery

Do not drink alcohol while taking Quviviq. Alcohol increases drowsiness and impairs coordination and judgement. Do not drive, cycle or operate machinery unless you feel completely alert, and avoid these activities if you have slept for fewer than seven hours after taking your tablet. Take particular care in the first few days of treatment while you learn how Quviviq affects you.

Other medicines

Tell us about every medicine you take, including anything bought without a prescription and any herbal products. Interactions of particular relevance include:

  • Moderate CYP3A4 inhibitors such as erythromycin, ciprofloxacin, diltiazem or ciclosporin, which may require the lower 25mg dose
  • CYP3A4 inducers such as rifampicin, carbamazepine, phenytoin or St John’s wort, which can make Quviviq considerably less effective
  • Other sleeping tablets and sedatives, which should not be combined with Quviviq
  • Medicines that cause drowsiness, including strong painkillers, some antihistamines and medicines for anxiety

Effects some people notice at the start of treatment

Sleep paralysis, hallucinations as you fall asleep or wake up, and brief episodes of muscle weakness can occur, mainly during the first few weeks. These experiences are not dangerous but can be distressing. Contact us or your GP if they happen so your treatment can be reviewed. If you have depression and your mood worsens, or you have any thoughts of harming yourself, seek medical advice immediately.

General safety

  • Keep out of the sight and reach of children
  • Never share your Quviviq tablets with anyone else, even if their symptoms sound the same as yours
  • Do not take more than one tablet in any 24 hour period
  • If you take too many tablets, contact 111 or attend your nearest A&E, taking the pack with you

Not sure whether Quviviq is right for you? Chat with us and our UK pharmacy team will talk it through, or Request Treatment to start your consultation.

Quviviq FAQs

How quickly does Quviviq work?

Quviviq reaches peak levels in the blood within one to two hours, and many people notice a difference within the first few nights. Take it within 30 minutes of going to bed. A heavy meal beforehand can delay how quickly it takes effect, so leave a gap after eating where you can.

Is Quviviq addictive?

Quviviq is not a benzodiazepine or a Z-drug. Clinical studies did not show evidence of dependence, tolerance, rebound insomnia or withdrawal symptoms, and it can normally be stopped without gradually reducing the dose. It is still a prescription medicine that should only be taken as directed, and we will always review whether you still need it.

Will Quviviq make me groggy the next morning?

Daridorexant has a half-life of around eight hours, which is shorter than several other sleep medicines, and next-day functioning was specifically measured in its clinical trials. Some people still notice sleepiness, particularly in the first few days. Allow at least seven hours in bed and avoid driving until you know how it affects you.

What is the difference between Quviviq 25mg and 50mg?

The standard adult dose is one 50mg tablet each night. The 25mg strength is prescribed where a lower dose is more appropriate, such as moderate liver impairment or when you are taking certain interacting medicines. Our prescriber decides which strength is suitable based on your consultation, so you do not need to choose yourself.

How many tablets are in a box?

Each box contains 30 film-coated tablets, which is a one month supply at one tablet per night. Both the 25mg and 50mg strengths are supplied in the same 30 tablet pack.

How long can I take Quviviq for?

Treatment should be as short as clinically necessary, and NICE advises reviewing it within three months of starting. Where it is working well, evidence supports continued benefit over 12 months with regular review. We will check in with you rather than simply repeating supply.

Can I drink alcohol while taking Quviviq?

No. Alcohol should be avoided while taking Quviviq. Combining the two increases drowsiness and impairs coordination and judgement, which raises the risk of accidents and falls.

How does Quviviq compare to zopiclone or zolpidem?

Zopiclone and zolpidem are Z-drugs that sedate the brain and are generally recommended for short-term use only, typically no longer than four weeks, because of the risk of tolerance and dependence. Quviviq works differently, by blocking the brain’s wake signal, and is assessed as an option for long-term insomnia. Which is appropriate depends on your history, and our prescriber will advise.

Do I need a prescription to get Quviviq UK-wide?

Yes. Quviviq is a prescription-only medicine, so it cannot be bought over the counter anywhere in the UK. Complete our online consultation and our prescriber will review your answers. If Quviviq is not suitable, we will explain why and discuss the alternatives with you.

What if I miss a dose?

If you forget to take your tablet at bedtime, skip that dose and take the next one the following evening as usual. Do not take a double dose, and do not take it in the middle of the night if you have fewer than seven hours left before you need to be awake.

Still have a question about Quviviq?

Request Treatment

Or chat with us and speak to a member of our UK pharmacy team.