Signup/Login

Tadalafil vs Sildenafil – What Do You Need to Know in 2025

  1. Home
  2. Tadalafil vs Sildenafil – What Do You Need to Know in 2025

Tadalafil vs Sildenafil – What Do You Need to Know in 2025

07 / Feb

Erectile dysfunction (ED) affects up to one in five men in the UK, impacting around 4.3 million individuals. However, this figure may be an underestimation, as many men hesitate to seek medical help, leading to under-reporting. In fact, some studies suggest the true prevalence could be as high as 41%—nearly two in five men.

Two of the most popular medications for ED are Tadalafil and Sildenafil. While both belong to the same drug class and work similarly, they have distinct differences in effectiveness, duration, and side effects. This blog provides a detailed comparison to help you make an informed decision.

 

What is Tadalafil?

Tadalafil is a medication used to treat erectile dysfunction (ED), benign prostatic hyperplasia (BPH), and pulmonary arterial hypertension (PAH). It belongs to a class of drugs called PDE5 inhibitors, which work by relaxing blood vessels to improve blood flow.

For erectile dysfunction, Tadalafil helps men achieve and maintain an erection by increasing blood flow to the penis when sexually stimulated. Unlike some other ED medications, it has a longer duration of action—lasting up to 36 hours—earning it the nickname the weekend pill.

For benign prostatic hyperplasia (BPH), Tadalafil helps relieve symptoms such as difficulty urinating by relaxing the muscles in the prostate and bladder.

It is available in different doses, including daily low-dose options for continuous effectiveness or higher doses for use as needed. Tadalafil is the active ingredient in Cialis, a well-known ED medication, but is also available as a generic drug.

 

What is Sildenafil?

Sildenafil usually known as Viagra is a medication used to treat erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). It belongs to a class of drugs known as PDE5 inhibitors, which work by relaxing blood vessels and increasing blood flow.

For erectile dysfunction, Sildenafil helps men achieve and maintain an erection when sexually stimulated by improving blood flow to the penis. It is the active ingredient in Viagra, one of the most well-known ED medications.

For pulmonary arterial hypertension (PAH), Sildenafil helps lower blood pressure in the lungs, making it easier for the heart to pump blood.

Sildenafil is not an aphrodisiac and does not increase sexual desire. It only works when there is sexual stimulation. It should not be taken with nitrates (used for heart conditions) or certain other medications due to the risk of a severe drop in blood pressure. Always consult a healthcare professional before use.

 

Tadalafil vs Sildenafil In a Nutshell

 

Sildenafil vs Tadalafil: What’s the Difference?

Sildenafil and Tadalafil are two of the most common medications used to treat erectile dysfunction (ED). Both belong to a class of drugs known as PDE5 inhibitors, which work by relaxing blood vessels and increasing blood flow to the penis. 

While they have similar functions, there are key differences in how they work, how long they last, and when they should be taken.

1. How Long They Last?

Sildenafil (Viagra): Lasts 4–6 hours

Tadalafil (Cialis): Lasts up to 36 hours

Note: Tadalafil is known as ‘the weekend pill’ because its effects can last much longer than Sildenafil.

2. How Quickly They Work?

Sildenafil: Takes effect in 30–60 minutes

Tadalafil: Takes effect in 30 minutes–2 hours, but some users may notice results sooner

Pro tip: Both should be taken about an hour before sex, but Tadalafil’s longer duration offers more flexibility.

Buy Cialis Online

3. How Are They Taken?

Sildenafil: 25-100mg, taken as needed

Tadalafil: 10-20mg for as-needed use; 5mg daily

Pro tip: Daily Tadalafil is a good option for men who want more spontaneity without planning around medication.

4. Effectiveness

Both medications are highly effective for ED, but Tadalafil may offer a more natural experience due to its longer window of action.

Pro tip: For men who want an erection on demand, Sildenafil may be better. For those who prefer long-lasting effects, Tadalafil is ideal.

Buy Viagra Online

5. Side Effects

Both medications share common side effects, such as:

  • Headache
  • Flushing
  • Nasal congestion
  • Indigestion
  • Dizziness
Note: Tadalafil may be more likely to cause muscle or back pain, while Sildenafil may lead to temporary vision changes.

Tadalafil vs Sildenafil: Dosage Schedule

Choosing the right dose of sildenafil or tadalafil depends on how your body responds and how often you need it. Here’s a guide to help you understand how much to take and when.

Sildenafil (Viagra) – Short-Acting, As Needed

Starting dose: 50mg

When to take it: Around one hour before sex

Adjustment: Can be increased to 100mg or lowered to 25mg depending on effectiveness and tolerance

Maximum dose: 100mg per day (never exceed this limit)

Duration of effect: 4–6 hours

Frequency: Once per day maximum

Important: Sildenafil works best on an empty stomach. Taking it with a heavy meal, especially one high in fat, may delay its effect.

Tadalafil (Cialis) – Longer-Lasting, Flexible Use

As-needed dose: 10mg at least 30 minutes before sex

Adjustment: Can be increased to 20mg or lowered to 10mg based on response

Maximum dose: 20mg per day

Duration of effect: Up to 36 hours

Frequency: Once per day maximum if taken as needed

Daily Use (for frequent sex):

Starting dose: 2.5mg to 5mg daily

How it works: Builds up in your system over a few days, allowing for spontaneous sexual activity

Best for: Those who have sex multiple times per week

Key Advantage: Tadalafil stays in your body longer, giving you a wider window for intimacy rather than needing to plan around a short timeframe.

Tadalafil vs Sildenafil: Which One is Best for You?

When choosing between sildenafil (Viagra) and tadalafil (Cialis), the decision often comes down to what matters most to you.

A study comparing the two found that sildenafil provided slightly firmer peak erections for some men. However, tadalafil offered a longer-lasting effect, which many participants preferred as it gave them more flexibility rather than a short window of peak performance.

So, the choice is simple:
– If you prioritise maximum firmness, sildenafil might have a slight edge.
– If you want a longer window of opportunity, tadalafil is likely the better fit.

There’s no one-size-fits-all answer—results vary from person to person. The best way to decide is to consider your needs, lifestyle, and how your body responds to each medication.

 

Consult with The Care Pharmacy for Your Erectile Dysfunction

If you’re struggling with erectile dysfunction, you’re not alone. At The Care Pharmacy, we offer discreet and professional support to help you find the right treatment while ensuring your privacy and well-being.

Our secure online platform makes it easy to access consultations and personalised ED treatments. Simply complete a short, confidential self-assessment to explore suitable options such as Sildenafil or Tadalafil.

You’ll receive a tailored treatment plan once reviewed by our UK-registered clinical team. If prescribed, your medication will be delivered directly to your door in discreet packaging, ensuring a hassle-free and private experience.

Take the first step towards restoring confidence and improving your sexual health today.

 

FAQs

Which is better Tadalafil or Sildenafil?

Tadalafil is just as effective as sildenafil in treating erectile dysfunction. However, comparison studies suggest that many men prefer Tadalafil over Sildenafil (50/100mg), likely due to its longer-lasting effects. With its extended duration of action, Tadalafil is increasingly becoming the preferred choice among phosphodiesterase inhibitors and may eventually overtake sildenafil as the go-to treatment for ED.

Is 20 mg Tadalafil equal to 100mg Viagra?

No, 20mg of Tadalafil is not the same as 100mg of Sildenafil (Viagra). While both medications treat erectile dysfunction (ED) by increasing blood flow to the penis, they work differently in terms of onset, duration, and effectiveness.

Does Tadalafil keep you hard after ejaculation?

No, Tadalafil does not keep you hard after ejaculation. It helps with erections when sexually stimulated but does not override the natural refractory period after ejaculation. However, it may reduce the time needed to get another erection.

Which pill is stronger Viagra or Cialis?

It depends on how you define “stronger.”

Viagra (Sildenafil) tends to provide a stronger peak erection for a shorter period (4–6 hours).

Cialis (Tadalafil) lasts much longer (up to 36 hours) but may not produce the same peak firmness as Viagra.

If you want maximum short-term potency, Viagra (sildenafil) 100mg is stronger. If you prefer longer-lasting effects, Cialis (tadalafil) 20mg is more effective.

What is the strongest erectile dysfunction medicine?

The strongest erectile dysfunction (ED) medication depends on dosage, duration, and effectiveness for the individual. Here’s a breakdown of the most potent options:

Sildenafil (Viagra) – Up to 100mg

  • Provides a strong, short-term effect
  • Lasts 4–6 hours
  • Best for peak firmness

Tadalafil (Cialis) – Up to 20mg

  • Lasts up to 36 hours (longest duration)
  • Allows for more natural, spontaneous activity

Vardenafil (Levitra) – Up to 20mg

  • Similar to Viagra but may work better for some men
  • Lasts 4–6 hours

Avanafil (Stendra) – Up to 200mg

  • Fastest onset (as quick as 15 minutes)
  • Lasts 6–12 hours
Written by:
  • Uzma Aslam
Medically reviewed by:
  • Mohammed Ismail Lakhi
Verified by:
  • Muhammed Luqman Asghar

Recent Posts

C0VID-19 Vaccine

The C0VID-19 vaccine works by training the immune system to recognise and fight the virus that causes C0VID-19, specifically its spike protein. C0VID-19 is a respiratory tract disease, mainly spread through respiratory droplets, aerosols, and direct contact with other people.

Price Per Dose: £ 59.99

Chickenpox Vaccine

Chickenpox is a common viral infection caused by the varicella zoster virus. This vaccine is suitable for adults and children aged between one and 65 years.

Price Per Dose: £ 74.99

Shingles Vaccine

Shingles vaccine helps to protect against getting shingles.Shingles is an infection that causes a painful rash and It’s suitable for adults aged 50 and above.

Price Per Dose: £ 219.99

Yellow Fever

Yellow fever is a viral disease caused by the yellow fever virus and transmitted through the bite of infected mosquitoes. It can lead to severe symptoms, including fever, headache, jaundice, and in severe cases, organ failure and death. Travelers visiting areas where yellow fever is endemic, particularly in tropical regions of Africa and South America, are at risk of contracting the disease. The yellow fever vaccine is a highly effective preventive measure for travelers. The typical dosing routine involves a single dose of the vaccine, which provides immunity for at least 10 years. Some countries require proof of yellow fever vaccination for entry. It is essential for travelers to get vaccinated before their journey to protect themselves and prevent the spread of the disease.

Price Per Dose: £ 69.99

Typhoid

Typhoid is a bacterial infection caused by the bacterium Salmonella Typhi. It spreads through contaminated food and water, and its symptoms include high fever, abdominal pain, and severe gastrointestinal issues. Travelers visiting regions with poor sanitation and inadequate hygiene standards are at a heightened risk of contracting typhoid. The typhoid vaccine is a crucial preventive measure for travelers. There are two types of typhoid vaccines available – the injectable vaccine and the oral vaccine. The typical dosing routine for the injectable vaccine involves a single shot. Get vaccinated against typhoid – it is essential for travelers to avoid the risk of infection and enjoy a safe and healthy journey.

Price Per Dose: £ 39.99

TBE (Tick-Borne Encephalitis)

Tick-borne encephalitis (TBE) is a viral disease transmitted to humans through the bite of infected ticks. It primarily affects the central nervous system and can lead to severe neurological symptoms, such as inflammation of the brain. Travelers visiting regions where TBE is endemic, especially during outdoor activities in wooded or grassy areas, face an increased risk of contracting the disease. The TBE vaccine provides effective protection against this potentially serious infection. The typical dosing routine involves a series of two to three doses, depending on the vaccine type used. Booster doses are also recommended to maintain immunity over time. Getting vaccinated against TBE is essential for travelers to mitigate the risk of infection and enjoy a safe and enjoyable trip.

Price Per Dose: £ 64.99

Rabies

Rabies is a deadly viral disease that affects the nervous system and is primarily transmitted through the bite of infected animals. The virus can cause a fatal infection if not treated promptly. Travelers, especially those visiting regions where rabies is prevalent and may have encounters with stray animals or wildlife, face an increased risk of contracting the disease. The Rabies vaccine is a preventive measure to protect against rabies. The typical dosing routine involves a series of doses. Typically this is given before potential exposure to the virus or after a potential exposure to ensure effective protection. Getting vaccinated against rabies is crucial for travelers to avoid the devastating consequences of this lethal infection and enjoy a safe journey.

Price Per Dose: £ 69.99

Pneumococcal (PCV/ PPSV)

The Pneumococcal vaccine, available as pneumococcal conjugate vaccine (PCV) and pneumococcal polysaccharide vaccine (PPSV), provides protection against various strains of pneumococcal bacteria. These bacteria can cause serious infections, including pneumonia, meningitis, and bloodstream infections. The PCV is primarily given to infants and young children, while PPSV is typically administered to older adults and individuals with specific medical conditions.

The typical dosing routine for PCV involves a series of doses given at specific ages during infancy. PPSV requires a single dose for most individuals, with a possible booster dose after a certain period.

Price Per Dose (PCV): £ 89.99

Price Per Dose (PPSV): £ 49.99

MMR

The MMR vaccine is a combination vaccine that provides protection against three highly contagious diseases: measles, mumps, and rubella. It is a crucial part of routine childhood immunizations. Also, it is recommended for adults who have not been vaccinated or lack immunity to these diseases. The typical dosing routine for the MMR vaccine involves two doses. The first dose is administered around the age of 12 to 15 months, and the second dose given between 4 to 6 years old. Getting vaccinated with the MMR vaccine is essential to prevent the spread of these potentially serious infections.

Ensure you and your loved ones are protected against measles, mumps, and rubella! Our experienced healthcare professionals are ready to provide you with the MMR vaccine. Come and get vaccinated with us to safeguard your health and contribute to a healthier community.

Price Per Dose: £ 44.99

Meningitis B

Meningitis B is a bacterial infection causing inflammation of the brain and spinal cord membranes. The risk of contracting it while traveling is generally low but increases in crowded settings. Be aware of the symptoms and ensure protection by getting vaccinated with us before your journey. Stay informed and stay safe during your travels.

Price Per Dose: £ 109.99

Meningitis ACWY

Meningitis ACWY is a bacterial infection that causes inflammation of the membranes surrounding the brain and spinal cord. The disease is caused by different types of bacteria, namely A, C, W, and Y. It can lead to severe health complications, including brain damage and death. Travelers, especially those visiting crowded settings like festivals, pilgrimages, or dormitory-style accommodations, may face an increased risk of contracting meningitis ACWY. To minimize the risk, vaccination is recommended, particularly when traveling to areas with active outbreaks or regions where the disease is more prevalent.

Price Per Dose: £ 49.99

Japanese Encephalitis

Japanese encephalitis is a viral infection transmitted through mosquito bites, primarily found in rural areas of Asia and the Western Pacific. The disease affects the brain and can lead to severe inflammation, resulting in neurological complications or even death. Travelers visiting or residing in regions where Japanese encephalitis is endemic, especially during the peak mosquito season, face an increased risk of contracting the virus. Taking preventive measures, such as using mosquito repellents, wearing protective clothing, and getting vaccinated, is crucial for travelers to reduce their risk of Japanese encephalitis and enjoy a safe journey.

The typical dosing for the Japanese encephalitis vaccine involves a two-dose series, with the second dose administered 28 days after the first.

Price Per Course: £ 199.99

HPV

Human papillomavirus (HPV) is a common viral infection that is primarily transmitted through sexual contact. There are multiple strains of HPV, some of which can lead to genital warts and others that can cause various cancers, including cervical, anal, and throat cancer. Travelers, especially those engaging in risky sexual behaviors, may be at risk of contracting HPV, as the virus can be prevalent worldwide. Practicing safe sex and getting vaccinated against HPV are essential preventive measures for travelers to reduce their risk of infection and the associated health complications.

Price Per Dose: £ 164.99

Hepatitis A Typhoid Combined

The Hepatitis A Typhoid combined vaccine is a convenient option for travelers seeking protection against both Hepatitis A and typhoid fever. The typical dosing schedule involves a single shot, providing immunity against both infections. This combination vaccine saves time and effort while ensuring comprehensive coverage against these travel-related diseases.

Price Per Course: £ 89.99

Hepatitis A Hepatitis B Combined

The Hepatitis A Hepatitis B combined vaccine offers protection against both Hepatitis A and Hepatitis B viruses. The typical dosing schedule involves three doses, administered at 0, 1, and 6 months. This vaccine is an excellent option for individuals seeking comprehensive protection against both hepatitis viruses in a convenient single shot.

Price Per Course: £249.99

Cholera

Cholera is a severe bacterial infection causing profuse watery diarrhea and vomiting, primarily transmitted through contaminated food and water. Traveling abroad increases the risk of contracting cholera. This is especially true in areas with poor sanitation or during outbreaks. Taking preventive measures such as getting vaccinated is crucial for travelers’ protection.

The Cholera vaccine is typically administered as two-doses, the first dose given at least one week before potential exposure to cholera and the second dose taken at least one week after the first dose.

Traveling to high-risk areas? Our trained healthcare professionals are here to help! Come and get your cholera vaccine today to ensure a safe and worry-free journey.

Price Per Course: £59.99

Hepatitis B

Hepatitis B is a viral liver infection primarily transmitted through infected blood or body fluids. Travelers and others in high-risk situations, such as unsafe medical procedures or unprotected sex, face an increased risk of contracting the virus. Vaccination against hepatitis B and adopting preventive measures are essential to safeguard against this serious infection.

The typical dosing for the hepatitis B vaccine involves a series of three doses. The initial dose is followed by a second dose at least one month later, and a third dose six months after the first dose. This vaccination provides long-term protection against hepatitis B.

Price Per Course: £149.99

Hepatitis A

Hepatitis A is a viral infection that primarily affects the liver, causing inflammation and potentially leading to symptoms like fever, nausea, and jaundice (yellowing of the skin and eyes). The virus is commonly transmitted through consuming contaminated food or water. While hepatitis A can occur anywhere, the risk of contracting it increases significantly when traveling abroad, especially to regions with poor sanitation and hygiene practices. Tourists may unknowingly consume contaminated food or water, putting them at risk of infection. It is crucial for travelers to be aware of the risk and take preventive measures, such as getting vaccinated against hepatitis A, to protect themselves during their journeys.

The typical dosing for the hepatitis A vaccine involves a two-dose series. The first dose is administered before potential exposure to the virus, and the second dose is given 6 to 18 months later to provide long-term immunity. For a booster dose, a single shot is usually recommended for ongoing protection after the initial series. Ensuring full vaccination with the recommended dosing schedule is essential to prevent hepatitis A infection and maintain immunity, especially when traveling to regions with a higher risk of the disease.

Price Per Dose: £59.99

Diptheria, Tetanus And Polio

Diphtheria, tetanus, and polio are significant infectious diseases to consider when traveling abroad. Diphtheria is a respiratory infection that causes breathing difficulties and potentially life-threatening complications. Tetanus, also known as “lockjaw,” induces severe muscle stiffness and spasms, transmitted through contaminated wounds. Polio is a viral infection that can lead to paralysis, impacting the nervous system. While vaccinations have controlled these diseases in many places, some regions may still pose risks.

Before traveling, it is recommended to get a single booster dose for diphtheria, tetanus, and polio. This reinforces immunity and reduces the risk of contracting these diseases in regions where they may still be prevalent. Ensure a safe and healthy journey by receiving the recommended booster before you travel.

Price Per Course: £39.99