Epiduo Gel

Price range: £19.99 through £28.00

Epiduo gel combines adapalene and benzoyl peroxide to treat acne with blocked pores and inflamed spots.

✓ Adapalene 0.1% + benzoyl peroxide 2.5%

✓ Choose a 45g or 60g tube

✓ Antibiotic-free prescription combination treatment

Earn up to 28 Points.

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Type of medicine

Topical gel used to treat mild to moderate acne.

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Active Ingredient

Adapalene and benzoyl peroxide – a retinoid and antimicrobial combination that unblocks pores, reduces inflammation, and targets acne-causing bacteria.

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Time to results

Early improvement may appear after 1–4 weeks; progress varies.

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Works by

Unclogging blocked pores, reducing skin inflammation, and killing acne-causing bacteria to help clear breakouts and prevent new ones from forming.

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Side effects

Common side effects include dryness, redness, peeling, and mild burning or stinging of the skin in the treated area.

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Not suitable for

Pregnancy, planned pregnancy or allergy to the ingredients. Avoid broken, eczematous or sunburned skin.

Buy Epiduo online

Request Epiduo gel from The Care Pharmacy after an online acne assessment. This listing is for the 0.1% adapalene and 2.5% benzoyl peroxide formulation, in 45g or 60g tubes. Check the price for your chosen size and explain which acne treatments you currently use.

How the combination works

Adapalene helps prevent pores becoming blocked and reduces inflammation. Benzoyl peroxide acts against acne-associated bacteria. Together they treat acne with blackheads, whiteheads and inflammatory spots, without an antibiotic ingredient.

Build a routine your skin can tolerate

Epiduo is usually applied once in the evening. Early improvement may appear after one to four weeks, but results vary and treatment needs a review. Dryness and irritation are common at the start; ask your prescriber about suitable moisturisers or changes to application frequency if needed.

Epiduo compared with Differin and Duac

Unlike Differin, Epiduo includes benzoyl peroxide as well as adapalene. Duac contains clindamycin instead of adapalene and has a different treatment limit. Do not combine these gels yourself: the right choice depends on your acne, previous response and tolerance.

Before requesting treatment

Tell us if you are pregnant, planning pregnancy, breastfeeding or using other skin medicines. This product is not the higher-strength 0.3% adapalene formulation. Tube size changes the amount supplied, not the strength or the instructions.

Further information: Epiduo patient leaflet, Epiduo prescribing information. Read the leaflet supplied with your medicine.

Directions

Apply a thin layer to clean, dry acne-affected skin once daily in the evening, as prescribed. Avoid eyes, lips, nostrils and damaged skin. Wash your hands afterwards. Do not apply extra for a missed dose. Ask for advice about moisturiser or less frequent use if irritation develops.

Ingredients

Adapalene 1mg/g (0.1%) and benzoyl peroxide 25mg/g (2.5%). The formulation includes propylene glycol and polysorbate 80, which may cause irritation or allergic reactions. Read the supplied leaflet for all ingredients.

Warnings

Do not use when pregnant or planning pregnancy. Stop and contact your prescriber if pregnancy occurs. Avoid broken, eczematous or sunburned skin, excessive sun and UV lamps. Do not combine with another retinoid or benzoyl peroxide product. The gel can bleach hair and fabrics.

Side Effects

Dryness, redness, peeling, stinging and burning can occur. Seek advice for persistent irritation. Stop and obtain urgent help for severe swelling, breathing problems or a serious skin reaction.

Storage

Store at or below 25°C, out of children’s reach. Follow the expiry date and after-opening instructions on your supplied pack; the product information specifies six months after first opening. Keep the container closed.

Epiduo is prescription-only. Complete the consultation so a prescriber can check whether this formulation is appropriate for your acne.

Adapalene 0.1% with benzoyl peroxide 2.5%. Both the 45g and 60g options have that strength.

No. It contains a retinoid, adapalene, and benzoyl peroxide, which has antimicrobial effects but is not an antibiotic.

Early improvement may appear after one to four weeks. Response varies; follow the treatment plan and arrange a review if acne is not improving.

Ask your pharmacist or prescriber about a gentle moisturiser and whether application frequency should change. Stop and seek advice for severe irritation.

Do not combine them yourself. Both contain adapalene and using them together may increase irritation.

No. Epiduo must not be used during pregnancy or when planning pregnancy. Ask for a suitable alternative.